For The Scientist
A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus
Robert R Graham, Sergey V Kozyrev, Emily C Baechler, MV Prasad Linga Reddy, Robert M Plenge, Jason W Bauer, Ward A Ortmann, Thearith Koeuth, Ma Francisca Gonzalez Escribano, the Argentine and Spanish Collaborative Groups, Bernardo Pons-Estel, Michelle Petri, Mark Daly, Peter K Gregersen, Javier Martin, David Altshuler, Timothy W Behrens & Marta E Alarcon-Riquelme
Nature Genetics - published online 16 April 2006; doi:10.1038/ng1782
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Fine mapping chromosome 16q12 in a collection of 231 systemic lupus erythematosus sibpair and multiplex families
Gillett CD, Langefeld CD, Williams AH, Ortmann WA, Graham RR, Rodine PR, Selby SA, Gaffney PM, Behrens TW, Moser KL
Genes & Immunity, February 2005, Volume 6, Number 1, Pages 19-23
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Genetic Association of the R620W Polymorphism of Protein Tyrosine Phosphatase PTPN22 with Human SLE
Chieko Kyogoku, Carl D. Langefeld, Ward A. Ortmann, Annette Lee, Scott Selby, Victoria E. H. Carlton, Monica Chang, Paula Ramos, Emily C. Baechler, Franak M. Batliwalla, Jill Novitzke, Adrienne H. Williams, Clarence Gillett, Peter Rodine, Robert R. Graham, Kristin G. Ardlie, Patrick M. Gaffney, Kathy L. Moser, Michelle Petri, Ann B. Begovich, Peter K. Gregersen, and Timothy W. Behrens
Am. J. Hum. Genet. 75:504–507, 2004
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Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus
Baechler EC, Batliwalla FM, Karypis G, Gaffney PM, Ortmann WA, Espe KJ, Shark KB, Grande WJ, Hughes KM, Kapur V, Gregersen PK, Behrens TW
Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2610-5.
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Recent advances in the genetics of systemic lupus erythematosus.
Gaffney PM, Moser KL, Graham RR, Behrens TW.
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Visualizing HLA Class II Risk Haplotypes in Human SLE
Robert R. Graham, Ward A. Ortmann, Carl D Langefeld, Damini Jawaheer, Scott A. Selby, Peter R. Rodine, Emily C. Baechler, Kristine E Rohlf, Katherine B. Shark, Rajan P. Nair, Philip E. Stuart, James T. Elder, Richard A. King, Kathleen L. Moser, Patrick M. Gaffney, Teodorica L. Bugawan, Henry A. Erlich, Steven S. Rich, Peter K. Gregersen, Timothy W. Behrens
Am J Hum Genet. 2002 Sep;71(3):543-53.
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Delineating the genetic basis of systemic lupus erythematosus.
Wakeland EK, Liu K, Graham RR, Behrens TW.
Immunity. 2001 Sep;15(3):397-408. Review.
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Genetic linkage and transmission disequilibrium of marker haplotypes at chromosome 1q41 in human systemic lupus erythematosus.
Graham RR, Langefeld CD, Gaffney PM, Ortmann WA, Selby SA, Baechler EC, Shark KB, Ockenden TC, Rohlf KE, Moser KL, Brown WM, Gabriel SE, Messner RP, King RA, Horak P, Elder JT, Stuart PE, Rich SS, Behrens TW
Arthritis Res. 2001;3(5):299-305.
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PARP alleles and SLE: failure to confirm association with disease susceptibility.
Criswell LA, Moser KL, Gaffney PM, Inda S, Ortmann WA, Lin D, Chen JJ, Li H, Gray-McGuire C, Neas BR, Rich SS, Harley JB, Behrens TW, Seldin MF.
J Clin Invest. 2000 Jun;105(11):1501-2. No abstract available.
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Genome screening in human systemic lupus erythematosus: results from a second Minnesota cohort and combined analyses of 187 sib-pair families.
Gaffney PM, Ortmann WA, Selby SA, Shark KB, Ockenden TC, Rohlf KE, Walgrave NL, Boyum WP, Malmgren ML, Miller ME, Kearns GM, Messner RP, King RA, Rich SS, Behrens TW.
Am J Hum Genet. 2000 Feb;66(2):547-56.
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A genome-wide search for susceptibility genes in human systemic lupus erythematosus sib-pair families.
Gaffney PM, Kearns GM, Shark KB, Ortmann WA, Selby SA, Malmgren ML, Rohlf KE, Ockenden TC, Messner RP, King RA, Rich SS, Behrens TW.
Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):14875-9.
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The genetics of human systemic lupus erythematosus.
Harley JB, Moser KL, Gaffney PM, Behrens TW.
Curr Opin Immunol. 1998 Dec;10(6):690-6. Review.
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The role of the clinical rheumatologist in the establishment of a large sibling pair resource for systemic lupus erythematosus.
Kearns GM, Messner RP, Behrens TW.
J Rheumatol. 1998 Mar;25(3):482-5.
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